The demand for soft tissue augmentation is rising along with the growing popularity of noninvasive facial rejuvenation. There is a wide range of facial fillers available in the United States from which to choose, including nonpermanent, semipermanent, and permanent dermal fillers. This review provides a general overview of soft tissue augmentation, evaluates various fillers, and discusses the evidence behind their efficacy to provide the cosmetic practitioner a better understanding of how to use fillers.