Prurigo is a group of severely pruritic skin disorders that often is debilitating for the patient and difficult to treat. Lesions may present with grouped excoriated papules and nodules that can mimic other skin disorders, such as dermatitis herpetiformis (DH). We report a case of a 46-year-old man who presented with multiple prurigo nodules and intense intractable pruritis with positive response to cyclosporine therapy.