Patients with hyperreactive skin on their face need products that bring relief and comfort to the skin. These cosmetic products must be adapted for sensitive skin, contain no fragrances, preservatives, or surfactants, and should be formulated using a small number of ingredients to avoid aggravating any existing contact dermatitis. The aim of the present open observational study conducted in Italy and in France was to assess the effectiveness and tolerance of a skin care program associating a cleansing lotion with a cream specifically adapted for the management of hyperreactive skin conditions.