Because lower extremity telangiectasia is often considered to be nothing more than a cosmetic nuisance, almost no attempts have been made to identify clinical features which reproducibly affect treatment outcomes. Long-term observations suggest that very small changes in vessel diameter (which are easily assessed using magnification and a measuring device specifically designed for that purpose) along with the awareness of the long-term impacts of previous treatments are particularly useful for predicting treatment outcomes. Telangiectatic etiologic heterogeneity, associated comorbidities, and several other poorly characterized variables are also discussed.