Hyaluronic acid (HA) fillers and botulinum toxin type A (BNT) are frequently used in the same anatomic site to provide durable and natural looking outcomes by combining volumizing and contouring with movement reduction. In the current pilot study, HA and BNT from one manufacturer was coadmin-istered simultaneously in a single syringe and needle into the crow’s-feet region. These data were compared to findings published earlier using products derived from a different manufacturer. These preliminary data confirm that regardless of the manufacturer, delivering combined HA and BNT simultaneously through a single syringe and needle to the crow’s-feet region of the face can result in highly acceptable cosmesis with half the number of needlesticks and high patient satisfaction. This technique may improve the patient experience by allowing the use of small-gauge needles and lessening the number of needlesticks incurred. Larger studies will better evaluate optimal techniques and safety/stability implications for administering simultaneous combination HA and BNT.