The removal of unwanted fat has been among the most popular aesthetic concerns since the advent of traditional tumescent liposuction. Recently developed energy-assisted techniques reduce downtime, improve safety, and provide better results. This study of 3 cases compares the efficacy and tolerability of 2 devices, Accent 980 Diode Laser by Alma Lasers (Accent 980) and SmartLipo MPX by Cynosure (SmartLipo MPX). Pretreatment protocols were similar in all 3 cases. No substantial adverse events were observed in any case. Equivalent results were obtained in all cases using the given treatment parameters, according to both the patient and the experienced physician administering treatment. On a 10-point scale, discomfort at day 1 after treatment was lower for Accent 980 in all 3 cases. Accent 980 can provide results equivalent to those seen with SmartLipo MPX but with less pain. Further study is warranted.