Excessive sweating (hyperhidrosis) is a frustrating problem for both the physician and patient. Easily underappreciated, this common skin disorder may be an occupational hazard and may adversely affect a patient’s self-esteem and quality of life. A variety of therapeutic options now exist that allow for safe and effective treatment of hyperhidrosis. We discuss topical, systemic, and iontophoretic therapies, as well as botulinum toxin type A injections and surgical interventions for the treatment of hyperhidrosis.