Atopic dermatitis is a common disorder that affects many individuals and has a variety of treatment options available for patients. Barrier skin protection has become a recognized modality to be part of the armamentarium for clinicians treating this condition. This article describes clinical study results for a novel barrier repair formulation. The patients in this trial displayed improvement in the signs and symptoms associated with atopic dermatitis over traditional moisturization, including improvement in transepidermal water loss. The novel barrier repair product presented in this article may be useful for patients suffering from atopic dermatitis.